Ebola Outbreak: MSF To Start West Africa Clinical Trials
Clinical trials to try to find an effective treatment for Ebola patients are to start in Africa next month. The medical charity Front...
http://www.africaeagle.com/2014/11/ebola-outbreak-msf-to-start-west-africa.html
Clinical trials to try to find an effective treatment for Ebola patients are to start in Africa next month.
The medical charity Frontieres, which has been helping lead the fight against the virus, says three of its treatment centres will host three separate research projects.
One trial involves using the blood of recovered Ebola patients to treat sick people in the Guinean capital Conakry.
Two antiviral drugs will be trialled in Guinea and an unconfirmed location.
"This is an unprecedented international partnership which represents hope for patients to finally get a real treatment," said MSF spokeswoman Dr Annick Antierens.
The first trials are due to start next month. Initial results could be available in February 2015.
The World Health Organization announced in September that experimental treatments and vaccines for Ebola should be fast-tracked.
Two experimental vaccines, produced by GlaxoSmithKline (GSK) and the Agency of Canada, have already been fast-tracked into safety trials.
The GSK vaccine is being tested in Mali, the UK and the US. Research on the Canadian vaccine is also under way in the US.
The three latest trials are:
At the Ebola centre in Conakry, Guinea, led by the Institute of Tropical Medicine (ITM), involving convalescent blood and plasma therapy - using blood from recovered patients containing antibodies that successfully fought off the virus to boost the patient's immune system.
At a site yet to be officially announced, funded by the Trust and led by the University of Oxford, using the antiviral drug brincidofovir. It works by interfering with the virus' ability to multiply. Up to 140 consenting patients will take the tablets twice a week over a two week period, and survival rates will be compared to those before the trial.
In Gueckedou, Guinea, led by the Institute of Health and Medical Research (Inserm), using the antiviral drug favipiravir.
Enormous task
There have been some anecdotal studies in previous outbreaks suggesting blood transfusions could benefit Ebola patients, but there is no scientifically proven evidence. This will be the first time there has been a human trial on any significant scale.
Speaking to the BBC from Conakry, lead researcher from ITM Johan van Griensven said:
"There are three important components [of this study] - the first is identifying Ebola survivors willing to donate blood. The second is the actual blood collection, and the third is the administration of the blood [to Ebola patients]."
However, organising safe blood donations in countries with decimated health systems is an enormous task.
Source: BBC Africa
The medical charity Frontieres, which has been helping lead the fight against the virus, says three of its treatment centres will host three separate research projects.
One trial involves using the blood of recovered Ebola patients to treat sick people in the Guinean capital Conakry.
Two antiviral drugs will be trialled in Guinea and an unconfirmed location.
"This is an unprecedented international partnership which represents hope for patients to finally get a real treatment," said MSF spokeswoman Dr Annick Antierens.
The first trials are due to start next month. Initial results could be available in February 2015.
The World Health Organization announced in September that experimental treatments and vaccines for Ebola should be fast-tracked.
Two experimental vaccines, produced by GlaxoSmithKline (GSK) and the Agency of Canada, have already been fast-tracked into safety trials.
The GSK vaccine is being tested in Mali, the UK and the US. Research on the Canadian vaccine is also under way in the US.
The three latest trials are:
At the Ebola centre in Conakry, Guinea, led by the Institute of Tropical Medicine (ITM), involving convalescent blood and plasma therapy - using blood from recovered patients containing antibodies that successfully fought off the virus to boost the patient's immune system.
At a site yet to be officially announced, funded by the Trust and led by the University of Oxford, using the antiviral drug brincidofovir. It works by interfering with the virus' ability to multiply. Up to 140 consenting patients will take the tablets twice a week over a two week period, and survival rates will be compared to those before the trial.
In Gueckedou, Guinea, led by the Institute of Health and Medical Research (Inserm), using the antiviral drug favipiravir.
Enormous task
There have been some anecdotal studies in previous outbreaks suggesting blood transfusions could benefit Ebola patients, but there is no scientifically proven evidence. This will be the first time there has been a human trial on any significant scale.
Speaking to the BBC from Conakry, lead researcher from ITM Johan van Griensven said:
"There are three important components [of this study] - the first is identifying Ebola survivors willing to donate blood. The second is the actual blood collection, and the third is the administration of the blood [to Ebola patients]."
However, organising safe blood donations in countries with decimated health systems is an enormous task.
Source: BBC Africa
